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Worm Perturb-Seq: massively parallel whole-animal RNAi and RNA-seq

https://doi.org/10.1038/s41467-025-60154-0

Zhang, Hefei; Li, Xuhang; Song, Dongyuan; Yukselen, Onur; Nanda, Shivani; Kucukural, Alper; Li, Jingyi Jessica; Garber, Manuel; Walhout, Albertha_J M (December 2025, Nature Communications)

Free, publicly-accessible full text available December 1, 2026
A comparative genomics multitool for scientific discovery and conservation

https://doi.org/10.1038/s41586-020-2876-6

Genereux, Diane P.; Serres, Aitor; Armstrong, Joel; Johnson, Jeremy; Marinescu, Voichita D.; Murén, Eva; Juan, David; Bejerano, Gill; Casewell, Nicholas R.; Chemnick, Leona G.; et al (November 2020, Nature)
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The Zoonomia Project is investigating the genomics of shared and specialized traits in eutherian mammals. Here we provide genome assemblies for 131 species, of which all but 9 are previously uncharacterized, and describe a whole-genome alignment of 240 species of considerable phylogenetic diversity, comprising representatives from more than 80% of mammalian families. We find that regions of reduced genetic diversity are more abundant in species at a high risk of extinction, discern signals of evolutionary selection at high resolution and provide insights from individual reference genomes. By prioritizing phylogenetic diversity and making data available quickly and without restriction, the Zoonomia Project aims to support biological discovery, medical research and the conservation of biodiversity.
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SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues

https://doi.org/10.1016/j.cell.2020.04.035

Ziegler, Carly G.K.; Allon, Samuel J.; Nyquist, Sarah K.; Mbano, Ian M.; Miao, Vincent N.; Tzouanas, Constantine N.; Cao, Yuming; Yousif, Ashraf S.; Bals, Julia; Hauser, Blake M.; et al (May 2020, Cell)
null (Ed.)
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